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Leptospira interrogans biofilm transcriptome highlights adaption to starvation and general stress while maintaining virulence | npj Biofilms and Microbiomes

Nature
Life-threatening Leptospira interrogans navigate a dual existence: surviving in the environment and infecting mammalian hosts.
3 months ago

Leucine-rich repeat proteins of Leptospira interrogans that interact to host glycosaminoglycans and integrins

Frontiers
This is the first report showing leptospiral LRR-proteins exhibiting GAG and integrin receptor-binding properties.
2 months ago

CRISPR-prime editing, a versatile genetic tool to create specific mutations with a single nucleotide resolution in Leptospira

ASM Journals
Leptospirosis, caused by pathogenic bacteria from the genus Leptospira, is a global zoonosis responsible for more than one million human...
5 months ago

Leptospira interrogans encodes a canonical BamA and three novel noNterm Omp85 outer membrane protein paralogs

Nature
We demonstrate that Leptospira interrogans encodes four distinct Omp85 proteins. The presumptive leptospiral BamA, LIC11623, contains a noncanonical POTRA4...
4 months ago

Effect of single and combination therapy on methanol extracts of Khaya senegalensis stem bark, Vernonia amygdalina leaves and Garcinia kola seed in Leptospira interrogans-infected mice

ScienceDirect.com
This study demonstrates the significant potential of Garcinia kola, Khaya senegalensis, and Vernonia amygdalina extracts singly and in combination to combat...
1 month ago

Host and Species-Specificities of Pattern Recognition Receptors Upon Infection With Leptospira interrogans

Frontiers
In this review, we will summarize these findings that suggest that in various hosts, leptospires differentially escape recognition by some Toll-like and NOD-...
7 months ago

Non-purulent myositis caused by direct invasion of skeletal muscle tissue by Leptospira in a hamster model

ASM Journals
ABSTRACTMyalgia is a common symptom of Leptospira infection in humans. Autopsies have reported that muscle tissue shows degeneration and necrosis of the...
4 months ago

Ketone body oxidation and susceptibility to ethyl acetoacetate in a novel hemolytic multidrug-resistant strain Leptospira interrogans KeTo originated from sewage water | Scientific Reports

Nature
We show oxidation of a wide array of organic acids including acetoacetate by a new strain of Leptospira interrogans designated as KeTo, isolated from a sewage...
3 months ago

Effect of single and combination therapy on methanol extracts of Khaya senegalensis stem bark, Vernonia amygdalina leaves and Garcinia kola seed in Leptospira interrogans-infected mice

ScienceDirect.com
Pastoralists in Nigeria mix Garcinia kola seed (GK), Khaya senegalensis stem bark (KS), and Vernonia amygdalina leaves (VA) to treat leptospirosis.
3 months ago

AMR mechanisms in L. interrogans serovars: a comprehensive study

Frontiers
Antimicrobial resistance (AMR) is one of the global health challenges of the 21st century. Data regarding AMR mechanisms in Leptospira...
9 months ago